Thermo Fisher Scientific Ubiquitin Polyclonal Antibody

Thermo Fisher Scientific Ubiquitin Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:500

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, chicken, canine, hamster, mouse, porcine, non-human primate, rat, rabbit, and Xenopus based on sequence homology.

Target Information

Ubiquitin is a highly conserved protein that plays a major role in targeting cellular proteins for degradation by the 26S proteasome. It is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein.
The gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a.
Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome.
Similarly, ribosomal protein L40 and S30 are synthesized as fusion proteins with ubiquitin or ubiquitin-like proteins. Multiple alternatively spliced transcript variants encoding the same proteins have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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