Thermo Fisher Scientific Survivin/BIRC5 Monoclonal Antibody (BIRC5/7778)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human fetal kidney, liver, lymphoma, or adenocarcinoma
• Cellular Location: Nucleus, Cytoplasm

Target Information

Survivin (also known as IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. IAPs are involved in multiple cellular functions including signaling, division, and metabolism, and are differentially expressed in nearly all human cancers but not in most normal tissues.
Survivin contains a single baculovirus IAP repeat (BIR) domain and lacks a C-terminal RING finger domain. It is highly expressed during fetal development and in most tumors, but low in adult tissues.
During the G2/M phase, Survivin associates with mitotic spindle microtubules, a process essential for its anti-apoptotic function. Disruption of this interaction increases caspase-3 activity, leading to apoptosis during mitosis.
Survivin is also expressed in adult rat brain tissues after traumatic injury and may regulate neural cell proliferation. Multiple transcript variants encoding distinct isoforms have been identified.
Overexpression of Survivin in cancer may bypass apoptotic checkpoints, supporting uncontrolled cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.