Thermo Fisher Scientific ZNF281 Polyclonal Antibody
ZNF281 단백질을 인식하는 Thermo Fisher의 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 및 랫트 시료에 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C 보관이 권장됩니다.
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- PA5116145
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZNF281 (Accession Q9Y2X9), corresponding to amino acid residues Q396–S446 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900779 |
Product Specific Information
Antibody detects endogenous levels of total Zfp281.
Target Information
ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression.
ZFP281 interacts with other transcription factors such as Sp1 to repress vimentin gene transcription and plays a key role in controlling embryonic stem cell pluripotency by directly regulating specific target genes.
It physically interacts with transcription factors POU5F1, Sox2, and NANOG. Gene expression microarray analysis indicates that ZFP281 can both activate and repress target genes, demonstrating bifunctional roles in gene regulation within stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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