Thermo Fisher Scientific ZEB1 Polyclonal Antibody
ZEB1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Thermo Fisher Scientific ZEB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human ZEB1 (Accession P37275), corresponding to amino acid residues P863–F913 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900778 |
Product Specific Information
Antibody detects endogenous levels of total ZEB1.
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression and modulates promoter activity of ATP1A1 depending on cell type and cDNA quantity. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription with CTBP1, positively regulates neuronal differentiation, and represses RCOR1 activation during neurogenesis. Mutations in ZEB1 can cause corneal dystrophy, posterior polymorphous corneal dystrophy, and Fuchs endothelial dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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