Thermo Fisher Scientific ARHGAP22 Polyclonal Antibody
인간 ARHGAP22 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 기반 용액 형태로 4°C 또는 -20°C 보관 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP22. Recombinant protein control fragment (Product #RP-103560) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638142 |
Product Specific Information
Immunogen sequence:
DNVPAPGLVP GIPSVASMAW SGASSSESSV GGSLSSCTAC RASDSSARSS LHTDWALEPS PLPSSSED
Highest antigen sequence identity to the following orthologs:
- Mouse: 66%
- Rat: 66%
Target Information
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down-regulation of their active form.
ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein localized to the cytoplasm, containing one Rho-GAP domain and one PH domain.
ARHGAP22 functions as a GTPase-activating protein for Rac1, converting it to an inactive GDP-bound state. Through interaction with ZNF161 (VEZF1), it may play a role in transcription regulation.
Multiple isoforms of ARHGAP22 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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