Thermo Fisher Scientific Kindlin-2 Polyclonal Antibody
Kindlin-2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IP 실험에 적합. 액상 형태로 4°C 보관. 세포 부착 및 신호전달 연구용으로 사용.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 to 225 of human Kindlin-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself.
Binds to membranes enriched in phosphoinositides.
Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes.
Required for the assembly of focal adhesions.
Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation.
Recruits FBLIM1 to focal adhesions.
Plays a role in the TGFB1 and integrin signaling pathways.
Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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