Thermo Fisher Scientific CREBL1 Monoclonal Antibody (4D10)
CREBL1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 4D10). Western blot, ICC/IF, ELISA에 적합하며, 인간 시료 반응성을 보임. UPR 경로 연구용으로 사용되며, 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D10 |
| Immunogen | CREBL1 (NP_004372.3, 2–88 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AELMLLSEIA DPTRFFTDNL LSPEDWGLQN STLYSGLDEV AEEQTQLFRC PEQDVPFDGS SLDVGMDVSP SEPPWELLPI FPDLQVK
Target Information
ATF6 beta (CREBL1) is a transcription factor involved in the unfolded protein response (UPR) pathway during ER stress.
It can form homodimers or heterodimers with ATF6-alpha, binding to ER stress response elements and interacting with nuclear transcription factor Y to activate UPR target genes.
ATF6 beta is typically located in the endoplasmic reticulum membrane; under stress, its N-terminal domain is cleaved and translocates to the nucleus.
Two transcript variants encoding different isoforms have been identified. The protein shares sequence similarity with the Creb/ATF subfamily of the bZip transcription factor superfamily and localizes to both cytoplasm and nucleus.
The gene is located within the MHC class III region on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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