Thermo Fisher Scientific ARTS1 Polyclonal Antibody
Human ERAP1(ARTS1) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF 분석에 적합. 1 mg/mL 농도의 액상 형태이며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol, 0.02% sodium azide) 기반, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERAP1 (Accession Q9NZ08), corresponding to amino acid residues M447–F497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852435 |
Product Specific Information
Antibody detects endogenous levels of total ERAP1.
Target Information
The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH₂-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides presented by MHC class I must be 8–11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is induced by interferon-gamma. The gene encoding human ERAP1 maps to chromosome 5q15.
ERAP1 has also been characterized as:
- Adipocyte-derived leucine aminopeptidase (A-LAP)
- Puromycin-insensitive leucine-specific aminopeptidase (PILS-AP)
- Aminopeptidase regulator of TNFR1 shedding (ARTS-1)
A-LAP may inactivate bioactive peptides such as angiotensin II, potentially regulating blood pressure. PILS-AP plays a role in angiogenesis by regulating endothelial cell proliferation and migration. ARTS-1 acts as a TNFR1 binding protein promoting TNFR1 shedding. Further research is required to fully elucidate the functions of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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