Thermo Fisher Scientific FZD7 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Rabbit, Opossum (100%); Platypus (94%); Chicken, Xenopus (89%).
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.
The FZD7 protein contains:

• An N-terminal signal sequence
• 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members
• 7 putative transmembrane domains
• An intracellular C-terminal tail with a PDZ domain-binding motif

FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.