Thermo Fisher Scientific TIAF1 Polyclonal Antibody
Human TIAF1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. KLH 결합 합성 펩타이드(aa 34-115)로부터 유래된 면역원 사용. 단백질 A 정제, 액상 형태, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TIAF1 (amino acids 34–115) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that inhibits the cytotoxic effects of TNF-alpha, TRADD, and FADD. It localizes to the nucleus and is significantly up-regulated in activated helper T lymphocytes (TH2) during chronic kidney and liver allograft rejection.
Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation.
TIAF1 is essential for p53- and WOX1-mediated cell death and plays a role in aggregation-dependent control of tumor progression, metastasis, and regulation of cell death.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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