ELK Biotechnology Paxillin (phospho Tyr31) rabbit pAb
Paxillin (phospho Tyr31) rabbit polyclonal antibody로, 인산화된 Tyr31 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. 세포골격 및 세포 부착 관련 연구에 적합합니다.
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제품명
Paxillin (phospho Tyr31) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PXN; Paxillin |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Paxillin around the phosphorylation site of Tyr31. AA range: 15–64 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 68 kD |
| Gene ID (Human) | 5829 |
| Human Swiss-Prot No. | P49023 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cytoskeleton; Cell junction, focal adhesion; Cytoplasm, cell cortex.
Colocalizes with integrins at the cell periphery and with PXN at membrane ruffles and the leading edge of migrating cells (PubMed:23128389).
배경 (Background)
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression patterns and have distinct biochemical and physiological properties (PMID:9054445).
[Provided by RefSeq, Aug 2011]
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