ELK Biotechnology p53 (phospho Ser9) rabbit pAb
인간 및 원숭이에 반응하는 p53 (phospho Ser9) rabbit polyclonal 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 p53 Ser9 인산화 부위 기반 면역원으로 제작되었으며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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ELK Biotechnology p53 (phospho Ser9) rabbit pAb
제품 개요
이 항체는 인간 p53 단백질의 Ser9 인산화 부위를 기반으로 제작된 rabbit polyclonal 항체입니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용 가능하며, 고순도 IgG 형태로 제공됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | p53 (phospho Ser9) rabbit pAb |
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human p53 around phosphorylation site of Ser9 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 7157 |
| Human Swiss-Prot No | P04637 |
| Species Reactivity | Human; Monkey |
세포 내 위치 (Cellular Localization)
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton, Centrosome.
Recruited into PML bodies with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440) and mitomycin C treatment (PubMed:27323408).
Isoform-specific localization:
- Isoform 1: Predominantly nuclear, also cytoplasmic with isoform 4
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, occasionally cytoplasmic
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) is a tumor suppressor protein containing transcriptional activation, DNA-binding, and oligomerization domains. It regulates expression of target genes in response to cellular stress, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations are linked to various human cancers, including Li-Fraumeni syndrome. Alternative splicing and promoter usage result in multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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