ELK Biotechnology p53 (phospho Ser315) rabbit pAb
p53 단백질의 Ser315 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, IP, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 암 연구 및 세포 스트레스 반응 연구에 적합.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology p53 (phospho Ser315) rabbit pAb
ELK Biotechnology p53 (phospho Ser315) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | p53 (phospho Ser315) rabbit pAb |
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p53 around the phosphorylation site of Ser315 (AA range: 281–330) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kDa |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
- Isoform 1: Nucleus, Cytoplasm. Predominantly nuclear but localizes to cytoplasm when expressed with isoform 4.
- Isoform 2: Nucleus, Cytoplasm. Mainly nuclear with minor cytoplasmic staining.
- Isoform 3: Nucleus, Cytoplasm. Nuclear in most cells but cytoplasmic in some.
- Isoform 4: Nucleus, Cytoplasm. Predominantly nuclear but translocates to cytoplasm.
Background
Tumor protein p53 (TP53) is a tumor suppressor protein with transcriptional activation, DNA binding, and oligomerization domains. It responds to various cellular stresses to regulate target gene expression, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in TP53 are linked to numerous human cancers, including hereditary conditions such as Li-Fraumeni syndrome.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.