ELK Biotechnology p27 (phospho Ser10) rabbit pAb

ELK Biotechnology p27 (phospho Ser10) rabbit pAb

제품 개요

본 항체는 인간 p27 Kip1 단백질의 Ser10 인산화 부위를 인식하는 rabbit polyclonal antibody입니다. 세포주기 조절 및 p27 관련 신호전달 연구에 적합합니다.

제품 정보

세포 내 위치 (Cellular Localization)

Nucleus, Cytoplasm, Endosome.
In quiescent cells, p27 is both nuclear and cytoplasmic. AKT- or RSK-mediated phosphorylation on Thr-198 promotes cytoplasmic translocation and cell cycle progression.
Phosphorylation on Ser-10 by UHMK1 facilitates nuclear export and cell cycle progression.
Phosphorylation on Tyr-88 and Tyr-89 induces nuclear translocation.
Colocalization at endosomes with SNX6 leads to lysosomal degradation (By similarity).

Background

This gene encodes a cyclin-dependent kinase inhibitor (CDKN1B/p27), which shares limited similarity with CDKN1A/p21.
The protein binds to and inhibits cyclin E-CDK2 or cyclin D-CDK4 complexes, controlling cell cycle progression at G1 phase.
Degradation of p27, triggered by CDK-dependent phosphorylation and ubiquitination by SCF complexes, is essential for transition from quiescence to proliferation.
Mutations in CDKN1B are associated with multiple endocrine neoplasia type IV (MEN4).
[provided by RefSeq, Apr 2014]