ELK Biotechnology NFκB-p105 (phospho Ser893) rabbit pAb
NFκB-p105 (phospho Ser893) rabbit polyclonal antibody는 인간 NF-kappaB p105/p50의 Ser893 인산화 부위를 인식합니다. WB, IHC, IF, ELISA에 적합하며, 핵 및 세포질 내 NFκB 위치 연구에 유용합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
NFκB-p105 (phospho Ser893) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NF-kappaB p105/p50 around the phosphorylation site of Ser893 (AA range: 860–909) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4790 |
| Human Swiss-Prot No | P19838 |
| Cellular Localization | Nucleus; Cytoplasm. Found in the nucleus and cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). |
| Species Reactivity | Human; Rat; Mouse |
Background
Nuclear factor kappa B subunit 1 (NFKB1) is a Homo sapiens gene encoding a 105 kDa protein that can undergo cotranslational processing by the 26S proteasome to produce a 50 kDa protein.
The 105 kDa protein acts as a Rel protein-specific transcription inhibitor, while the 50 kDa protein functions as a DNA-binding subunit of the NF-kappa-B (NFKB) complex.
NFKB is a transcription regulator activated by various stimuli such as cytokines, oxidant-free radicals, UV irradiation, and bacterial or viral products.
Activated NFKB translocates into the nucleus to stimulate gene expression involved in diverse biological functions.
Aberrant activation of NFKB is linked to inflammatory diseases, while persistent inhibition results in improper immune cell development or delayed cell growth.
Alternative splicing leads to multiple transcript variants encoding different isoforms.
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