ELK Biotechnology Met (phospho Tyr1349) rabbit pAb
Met 단백질의 Tyr1349 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, ELISA, IHC에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포막 단백질 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Met (phospho Tyr1349) rabbit pAb
제품 개요
Met 단백질의 Tyr1349 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다. 다양한 종의 시료에서 Western blot, ELISA, IHC 분석에 사용할 수 있습니다.
상세 정보
| 항목 | 내용 |
|---|---|
| Product name | Met (phospho Tyr1349) rabbit pAb |
| Alternative Names | MET; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human Met around the phosphorylation site of Tyr1349 (AA range: 1316–1365) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 155 kDa |
| Gene ID (Human) | 4233 |
| Human Swiss-Prot No. | P08581 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [Isoform 3]: Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which reduces lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, playing a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
(RefSeq, May 2016)
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