ELK Biotechnology MEK-4 (phospho Thr261) rabbit pAb
MEK-4 (phospho Thr261) rabbit pAb는 인산화된 Thr261 부위를 인식하는 폴리클로날 항체로, MAPK 신호전달 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며 인간, 마우스, 랫트 시료에 반응합니다. 세포 내 국소화 연구 및 단백질 발현 분석에 활용됩니다.
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제품명
MEK-4 (phospho Thr261) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SEK1/MKK4 around the phosphorylation site of Thr261 (AA range: 227–276) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| Gene ID (Human) | 6416 |
| Human Swiss-Prot No. | P45985 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)
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