ELK Biotechnology HDAC5 (phospho Ser498) rabbit pAb
인산화 Ser498 부위에 특이적인 HDAC5 rabbit polyclonal antibody. WB, IHC, IF, ELISA 등 다양한 응용 가능. 핵과 세포질 간 이동 특성 연구에 적합. 인간 및 생쥐 시료 반응성 보유.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology HDAC5 (phospho Ser498) rabbit pAb
제품명
HDAC5 (phospho Ser498) rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498 (AA range: 464–513) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 122 kD |
| GeneID (Human) | 10014 |
| Human Swiss-Prot No | Q9UQL6 |
| Cellular Localization | Nucleus, Cytoplasm. Shuttles between nucleus and cytoplasm. In muscle cells, it translocates to cytoplasm during myocyte differentiation. Export depends on interaction with 14-3-3 chaperone and phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1, and SIK1. |
| Species Reactivity | Human; Mouse |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
The HDAC5 protein belongs to the class II histone deacetylase family, exhibiting histone deacetylase activity and repressing transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 and may form multicomplex proteins.
HDAC5 interacts with myocyte enhancer factor-2 (MEF2) proteins, repressing MEF2-dependent genes. It is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.