ELK Biotechnology EGFR (phospho Tyr1197) rabbit pAb
EGFR (phospho Tyr1197) rabbit pAb는 인산화된 EGFR Tyr1197 부위를 인식하는 폴리클로날 항체입니다. Western blot, IHC, IF, ELISA에 사용 가능하며 인간, 마우스, 랫트에 반응합니다. 세포막 및 핵막 등 다양한 세포 위치에서 EGFR 단백질 검출에 적합합니다.
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제품명
EGFR (phospho Tyr1197) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1197 (AA range: 1161–1210) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane.
Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
배경 (Background)
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily.
This protein is a receptor for members of the epidermal growth factor family.
EGFR is a cell surface protein that binds to epidermal growth factor.
Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation.
Mutations in this gene are associated with lung cancer.
[Provided by RefSeq, Jun 2016]
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