ELK Biotechnology Caveolin-1 (phospho Tyr14) rabbit pAb
Caveolin-1 (phospho Tyr14) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 다클론 항체로, 인산화된 Caveolin-1의 Tyr14 부위를 인식합니다. WB와 ELISA에 적합하며, 세포막 및 골지체 막 단백질 연구에 활용됩니다. -20℃에서 1년 보관 가능합니다.
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Caveolin-1 (phospho Tyr14) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caveolin-1 (phospho Tyr14) rabbit pAb |
| Alternative Names | CAV1; CAV; Caveolin-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Tyr14. AA range: 5-54 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kD |
| GeneID (Human) | 857 |
| Human Swiss-Prot No | Q03135 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
Background
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, initiating the coupling of integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAPK cascade. Caveolin-1 and Caveolin-2 are located adjacently on chromosome 7, forming a stable hetero-oligomeric complex. Mutations in this gene are associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of Caveolin-1.
(Source: RefSeq, Mar 2010)
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