ELK Biotechnology Calnexin (phospho Ser583) rabbit pAb
Calnexin (phospho Ser583) rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에 반응. WB, IHC, IF, ELISA에 사용 가능. ER 막 단백질의 인산화 상태 연구에 적합. 고순도 IgG, 1 mg/ml 농도로 제공.
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Calnexin (phospho Ser583) rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Calnexin (phospho Ser583) rabbit pAb |
| Alternative Names | CANX; Calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human Calnexin around the phosphorylation site of Ser583 (AA range: 543–592) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kDa |
| GeneID (Human) | 821 |
| Human Swiss-Prot No | P27824 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Endoplasmic reticulum membrane; Single-pass type I membrane protein; Endoplasmic reticulum; Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065).
The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
Background
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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