ELK Biotechnology ASK 1 (phospho Ser966) rabbit pAb
ASK1 (phospho Ser966) rabbit polyclonal antibody로, MAPK 신호전달 경로 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인산화 Ser966 부위 특이적 인식. 인체 및 마우스, 랫트 시료에 반응하며, 고순도 IgG 형태로 제공됩니다.
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제품명
ASK 1 (phospho Ser966) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against a synthesized peptide derived from human ASK1 around the phosphorylation site of Ser966 (AA range: 932–981). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 155 kD |
| Gene ID (Human) | 4217 |
| Human Swiss-Prot No. | Q99683 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. |
Background
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream kinase, MAPK kinase/MEK, which in turn activates MAPK. These kinases are highly conserved across species including yeast, Drosophila, and mammals.
MAPKKK5 (ASK1) contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
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