ELK Biotechnology Cortactin (Acetyl Lys235) rabbit pAb

Cortactin (Acetyl Lys235) Rabbit Polyclonal Antibody

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytoskeleton, cell projection (lamellipodium, ruffle, dendrite, podosome), cell membrane (peripheral membrane protein, cytoplasmic side), cell junction (focal adhesion), membrane (clathrin-coated pit), dendritic spine, cytoplasm (cell cortex).
Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis.

Background

Cortactin (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein localizes in the cytoplasm and at cell-substratum contact areas. It plays dual roles in:

1. Regulating interactions between components of adherens-type junctions
2. Organizing the cytoskeleton and cell adhesion structures of epithelial and carcinoma cells

During apoptosis, the protein is degraded in a caspase-dependent manner. Aberrant regulation contributes to tumor cell invasion and metastasis. Three splice variants encoding different isoforms have been identified (RefSeq, May 2010).