Thermo Fisher Scientific PAR4 Monoclonal Antibody (3G9H7,4H12E9)
PAR4 단백질을 표적으로 하는 인간 반응성 마우스 단클론 항체. Western blot, IHC, ELISA 등 다양한 응용 가능. 비결합형 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관 권장. 연구용으로만 사용.
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- MA515408
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G9H7, 4H12E9 |
| Immunogen | Purified recombinant fragment of PAR4 (aa1–330) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10985652 |
Product Specific Information
MA5-15408 targets PAR4 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen used is a purified recombinant fragment of PAR4 (aa1–330) expressed in E. coli.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
Intracellularly, it inhibits pro-survival pathways and activates Fas-mediated apoptosis.
Extracellularly, the secreted form binds to glucose-regulated protein 78 (GRP78) on the cell surface, activating the extrinsic apoptotic pathway.
The gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated in various tumors.
It also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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