ELK Biotechnology Cleaved-MMP-1 22k (F100) rabbit pAb
Cleaved-MMP-1 22k (F100) rabbit pAb는 인간, 생쥐, 랫트 시료에서 MMP-1 단백질의 절단형을 검출하는 폴리클로날 항체입니다. WB 및 ELISA에 사용 가능하며, 고순도 IgG 형태로 제공됩니다. 세포외기질 분해 관련 연구에 적합합니다.
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Cleaved-MMP-1 22k (F100) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-MMP-1 22k (F100) rabbit pAb |
| Alternative Names | MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP1. AA range: 81-130 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kD |
| Gene ID (Human) | 4312 |
| Human Swiss-Prot No | P03956 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix |
| Species Reactivity | Human; Rat; Mouse |
Background
Matrix metallopeptidase 1 (MMP1) Homo sapiens
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
[provided by RefSeq, Jan 2016]
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