ELK Biotechnology Cleaved-Integrin α6 LC (E942) rabbit pAb
Cleaved-Integrin α6 LC (E942) rabbit pAb는 인간 ITGA6 유래 펩타이드로 제작된 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 세포막 단백질 검출에 유용하며, 28kD 밴드 확인. Human, Rat, Mouse 반응성.
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Cleaved-Integrin α6 LC (E942) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Integrin α6 LC (E942) rabbit pAb |
| Alternative Names | ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ITGA6 (AA range: 923-972) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 28 kD |
| GeneID (Human) | 3655 |
| Human Swiss-Prot No | P23229 |
| Cellular localization | Cell membrane; Single-pass type I membrane protein; Lipid-anchor |
| Species Reactivity | Human; Rat; Mouse |
Background
Integrin subunit alpha 6 (ITGA6) Homo sapiens.
This gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Oct 2015]
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