ELK Biotechnology Cleaved-MMP-14 (Y112) rabbit pAb
Cleaved-MMP-14 (Y112) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체입니다. Western blot과 ELISA에 적합하며, 세포막 및 세포질에 존재하는 MMP-14 단백질 검출에 사용됩니다. 종양 침습 및 MMP2 활성화 연구에 활용 가능합니다.
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Cleaved-MMP-14 (Y112) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-MMP-14 (Y112) rabbit pAb |
| Alternative Names | MMP14; Matrix metalloproteinase-14; MMP-14; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP14. AA range: 93-142 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| Gene ID (Human) | 4323 |
| Human Swiss-Prot No. | P50281 |
| Cellular Localization | Membrane; Single-pass type I membrane protein; Melanosome; Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. |
| Species Reactivity | Human; Mouse; Rat |
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
[provided by RefSeq, Jul 2008]
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