ELK Biotechnology Cleaved-COL1A2 (G1102) rabbit pAb

제품명

Cleaved-COL1A2 (G1102) rabbit pAb

공급업체

ELK Biotechnology

제품 설명

Cleaved-COL1A2 (G1102) rabbit pAb는 인간 Collagen I alpha2에서 유래한 합성 펩타이드(AA 1053–1102)에 대해 생성된 폴리클로날 항체입니다. Type I collagen α2 chain은 대부분의 결합 조직에서 발견되는 섬유형 콜라겐으로, 골격, 각막, 진피 및 힘줄에 풍부하게 존재합니다. 이 유전자의 변이는 골형성부전증, Ehlers-Danlos 증후군, 특발성 골다공증 등 다양한 질환과 연관되어 있습니다.

제품 스펙

Background

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene tend to be less severe than those in COL1A1, reflecting the different roles of alpha2 chains in matrix integrity. Three transcripts, resulting from alternate polyadenylation signals, have been identified.