ELK Biotechnology Cleaved-Caspase-5 p10 (S331) rabbit pAb
Cleaved-Caspase-5 p10 (S331) rabbit pAb는 인간 Caspase-5 유래 펩타이드로 제작된 폴리클로날 항체입니다. WB와 ELISA에 적합하며, 세포 사멸 관련 단백질 검출에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능하며 Human, Rat, Mouse 반응성을 가집니다.
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Cleaved-Caspase-5 p10 (S331) rabbit pAb
Supplier: ELK Biotechnology
제품 개요
Cleaved-Caspase-5 p10 (S331) rabbit pAb는 인간 Caspase-5 유래 합성 펩타이드(AA 312–361)에 대해 생산된 폴리클로날 항체로, 세포 사멸 과정에서 활성화된 Caspase-5 단백질을 검출하는 데 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-5 p10 (S331) rabbit pAb |
| Alternative Names | CASP5; ICH3; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase 5 (AA range: 312–361) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 10 kD |
| Gene ID (Human) | 838 |
| Human Swiss-Prot No | P51878 |
| Cellular Localization | Neuron projection, neuronal cell body, IPAF inflammasome complex, NLRP1 inflammasome complex, NLRP3 inflammasome complex, AIM2 inflammasome complex |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a component of the Myc/Max/Mad transcription regulation network, is cleaved by this protein during Fas-mediated dephosphorylation. Expression is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [RefSeq, Aug 2010]
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