ELK Biotechnology Cleaved-Caspase-8 (D384) rabbit pAb
Cleaved-Caspase-8 (D384) rabbit pAb는 인간 Caspase-8 단백질의 절단형을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능하며 세포자멸사 연구에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 -20°C에서 1년 보관 가능합니다.
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Cleaved-Caspase-8 (D384) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-8 (D384) rabbit pAb |
| Alternative Names | CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB 1:500–2000, IF 1:50–300, IHC 1:50–300 |
| Immunogen | Synthesized peptide derived from human Caspase 8 (AA range: 335–384) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 47 + 55 kD |
| Gene ID (Human) | 841 |
| Human Swiss-Prot No. | Q14790 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain suggests interaction with Fas-interacting protein FADD. Detected in the insoluble fraction of the affected brain region from Huntington disease patients, implicating a role in neurodegenerative diseases.
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