Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), Magnetic beads, TrueMAB
c-Myc 단백질을 인식하는 마우스 단클론 항체로, Magnetic beads에 결합되어 IP 실험에 최적화됨. Human 시료 반응성. 단백질 G 정제, 5 mg/mL 농도, PBS/0.1% BSA/50% glycerol buffer. -20°C 보관.
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Applications
- Immunoprecipitation (IP): Assay-dependent
Publications
- Miscellaneous PubMed (Misc): 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to C-terminal amino acids 408–432 of human c-Myc |
| Conjugate | Magnetic beads |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
Synthetic peptide EQKLISEEDL conjugated to KLH.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays key roles in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK
- Vasculogenesis and angiogenesis during tumor development
c-Myc overexpression is associated with multiple cancers, including lung, breast, and colon carcinomas, and its translocation is implicated in Burkitt’s lymphoma and other B-cell proliferative disorders. Antibodies recognizing c-Myc epitopes are widely used for detecting Myc-tagged fusion proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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