Thermo Fisher Scientific Human Amyloid Precursor Protein Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human APP.
PEP-0048 can be used as a blocking peptide with polyclonal antibody PA5-19923.

Target Information

Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases produces beta amyloid, the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease.
Abnormal regulation and processing of APP also play roles in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.