Thermo Fisher Scientific PKC beta-1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC

• Storage guidance:

  • Short-term: 2–8°C에서 최대 1주 보관
  • Long-term: -20°C에서 소분 보관하여 동결-해동 반복 방지

• Predicted homology:
  Cow: 100%
  Human: 100%
  Mouse: 100%
  Pig: 100%
  Rabbit: 93%
  Rat: 100%

Target Information

The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.

PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters.

Each PKC family member has a specific expression profile and distinct cellular role. The PKC beta-1 isoform is reported to participate in B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice suggest roles in neuronal regulation and stress-related behavioral responses. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.