Thermo Fisher Scientific PSMB6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence: TTIMAVQFDG GVVLGADSRT TTGSYIANRV TDKLTPIHDR IFCCRSGSAA
• Storage guidance:
  • Short-term: Store at 2–8°C up to 1 week
  • Long-term: Store at -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 93%

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins in eukaryotic cells, while other proteins are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31) complex with an approximate molecular weight of 2.5 MDa. It consists of a 20S proteolytic core complex capped by 19S regulatory subunits that recognize ubiquitinated proteins and facilitate unfolding and translocation into the 20S core.
The PA28/11S REG Activator complex (α, β, γ subunits) enhances 20S core activity.
Defects in the ubiquitin-proteasome pathway are linked to several genetic diseases, including cystic fibrosis (CFTR), Angelman’s syndrome (E6-AP), and Liddle syndrome (ENaC).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.