Thermo Fisher Scientific gamma Adducin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
ASSVSQIQSQ TQSPQNVPEK LEENHELFSK SFISMEVPVM VVNGKDDMHD VEDELAKRVS RLSTSTTIEN IEITIKSPEK IEEVLSPE

Antigen sequence identity:

• Mouse: 84%
• Rat: 83%

Target Information

Adducins are heteromeric proteins composed of alpha, beta, and gamma subunits, encoded by distinct genes. These membrane skeletal proteins participate in the assembly of the spectrin-actin network in erythrocytes and epithelial tissues.

• Alpha and gamma adducins are ubiquitously expressed, while beta adducin is restricted to brain and hematopoietic tissues.
• Adducin was first purified from human erythrocytes as a heterodimer of alpha and beta subunits.
• Polymorphisms in these subunits are linked to blood pressure regulation in hypertension models.
• Heterodimers of alpha and gamma subunits have also been described.
• Structurally, adducin subunits have a protease-resistant N-terminal domain and a protease-sensitive C-terminal domain containing phosphorylation sites, a calmodulin binding site, and regions required for spectrin-actin association.
• Alternatively spliced gamma adducin isoforms exist, though their specific functions remain unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.