Thermo Fisher Scientific HDAC1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-860 detects histone deacetylase 1 (HDAC1) from human, mouse, rat, hamster, and canine tissues and cells.
It has been successfully used in Western blot, immunoprecipitation, ChIP, immunofluorescence, immunocytochemistry, and immunohistochemistry.
By Western blot, this antibody detects an ~62 kDa protein representing HDAC1 from HeLa cell lysate.
Immunocytochemical staining of HDAC1 in HeLa cells with PA1-860 results in nuclear staining.

The immunogen is a synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1.
This immunizing peptide (Cat. # PEP-069) is available for use in neutralization and control experiments.

Target Information

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression.
HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex.
It interacts with the retinoblastoma tumor-suppressor protein, forming a complex that regulates cell proliferation and differentiation.
Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.