Thermo Fisher Scientific UGT1A4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF
• Positive Samples: Mouse liver, Mouse stomach, Rat liver
• Cellular Location: Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein

Target Information

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
The gene locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are pseudogenes, and nine functional exons may be spliced to the four common exons, generating proteins with different N-termini and identical C-termini.
Each first exon encodes the substrate binding site and is regulated by its own promoter. This enzyme exhibits glucuronidase activity towards bilirubin and is more active on amines, steroids, and sapogenins.

주의사항

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• PA5-90760_UGT1A4_P22310-1_Rabbit.svg
• PA5-90760_UGT1A4_P22310-1_Rabbit_PDP.jpeg