Thermo Fisher Scientific CaMKIV Recombinant Rabbit Monoclonal Antibody (001)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:250–1:1,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Mouse CaM Kinase 4/CaMKIV.

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.

The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees.

In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT).

CaMKIV is encoded, along with calspermin, by the CaMKIV gene. In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a potential role in chromatin remodeling during nuclear condensation in spermatids.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.