Thermo Fisher Scientific P2X6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human P2X6 receptor. Validated for WB and IHC at 10–50 µg/mL. Lyophilized form, reconstitutable in sterile water. High sequence identity with mouse P2X6. Suitable for research use in ion channel and skeletal muscle ...
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | – |
| Immunohistochemistry (IHC) | 10–50 µg/mL | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 350–400 of human P2X6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at −20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen shares 90% identity with mouse sequence.
- Specificity: P2RX6.
Target Information
P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is composed of a trimer of subunits (P2X1–7), all sharing two transmembrane domains.
The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels mediating rapid and selective permeability to cations.
P2rx6 is predominantly expressed in skeletal muscle and regulated by p53. It associates with VE-cadherin at adherens junctions of human umbilical vein endothelial cells.
Alternative splicing results in multiple transcript variants of P2rx6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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