Thermo Fisher Scientific RAP1 Polyclonal Antibody
RAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며 사람, 마우스, 랫트 반응성. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from internal region of mouse RAP1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water and centrifuge to remove any insoluble material.
Specificity: RAP1.
Target Information
Human Rap1 is the first identified ortholog of the yeast telomeric protein scRap1, sharing three conserved sequence motifs. HRap1 is located at telomeres and regulates telomere length through recruitment by TRF2 rather than direct binding. The hRap1 cDNA encodes a 399-amino-acid protein (~47 kDa) that does not interact with TRF1.
TRF2, a ubiquitously expressed protein with a Myb-related DNA-binding motif, binds duplex TTAGGG repeats and localizes to all human telomeres. TRF2 helps maintain telomere terminal structure and prevents senescence in primary human cells. Inhibition of TRF2 induces apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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