Thermo Fisher Scientific Periplakin Polyclonal Antibody
Thermo Fisher Scientific의 Periplakin Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB, ICC/IF, ELISA에 적합합니다. Rabbit IgG 기반의 액상 항체로, 고순도 친화 크로마토그래피로 정제되었습니다. 세포접합부 및 세포골격 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–130 of human PPL (NP_002696.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.99 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913822 |
Product Specific Information
- Positive test controls: Mouse lung, Mouse heart
- Localization: Cell junction, Cell membrane, Cytoplasm, Mitochondrion, Nucleus, Cytoskeleton, Desmosome
Immunogen sequence:
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA KMQSDLARLQ EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG DMIAEDIRQL KERVTNLRGK HKQIYRLAVK
Target Information
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes.
Its N-terminal domain interacts with the plasma membrane, and the C-terminus interacts with intermediate filaments.
Through its rod domain, it forms complexes with envoplakin and may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.
AKT1/PKB, a protein kinase mediating cell growth and survival signaling, is reported to interact with this protein, suggesting a possible role as a localization signal in AKT1-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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