Thermo Fisher Scientific ARC Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Positive test controls include: SW620, Mouse heart.
The target is usually found in the following locations: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum, nucleolus.

Immunogen sequence:
MGNAQERPSE TIDRERKRLV ETLQADSGLL LDALLARGVL TGPEYEALDA LPDAERRVRR LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE AEPEPELEPE PDPEPEPDFE ERDESEDS

Target Information

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.
Isoform 1 is involved in RNA splicing.
Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.

ARC inhibits extrinsic apoptotic pathways in two ways:

1. By interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
2. By interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.

ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.

Mutations affecting the gene can result in myoclonus, familial cortical disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.