Thermo Fisher Scientific ARC Polyclonal Antibody
ARC 단백질을 표적으로 하는 Thermo Fisher의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C 보관. 세포사멸 억제 단백질 연구용.
- 카탈로그번호
- PA5120251
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–208 of human NOL3 (NP_003937.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913823 |
Product Specific Information
Positive test controls include: SW620, Mouse heart.
The target is usually found in the following locations: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum, nucleolus.
Immunogen sequence:
MGNAQERPSE TIDRERKRLV ETLQADSGLL LDALLARGVL TGPEYEALDA LPDAERRVRR LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE AEPEPELEPE PDPEPEPDFE ERDESEDS
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.
Isoform 1 is involved in RNA splicing.
Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways in two ways:
- By interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- By interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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