Thermo Fisher Scientific PLEKHO1 Monoclonal Antibody (3D5)

Thermo Fisher Scientific PLEKHO1 Monoclonal Antibody (3D5)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:

MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG DQLYISEKEV KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS KQPGNTAPNL IFLAVSPEEK ESWINALNSA ITRAKNRILD EVTVEEDSYL AHPTRDRAKI QHSRRPPTRG HLMAVASTST SDGMLTLDLI QEEDPSPEEP TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL SRPWEKTDKG ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ LLLETERLLG EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP HSQYRKSLM

Target Information

CKIP1 was identified through a yeast-two hybrid screening as a protein that interacts selectively with one catalytic subunit of the casein kinase 2 complex.
It is a pleckstrin homology domain-containing protein localized in the nucleus and plasma membrane, interacting with CK2α but not CK2α’.
CKIP1 plays roles in muscle differentiation, cell morphology regulation, and actin cytoskeleton organization.
It also interacts with ATM, recruiting nuclear ATM to the plasma membrane, and may regulate ATM function.
Additionally, CKIP1 forms a complex with AKT, leading to down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: H00051177-M01A_PLEKHO1_Q53GL0-1_House_mouse.svg)
(이미지 파일: H00051177-M01A_PLEKHO1_Q53GL0-1_House_mouse_PDP.jpeg)