Thermo Fisher Scientific SNF1 Polyclonal Antibody
Thermo Fisher Scientific의 SNF1 Polyclonal Antibody는 효모 SNF1 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot 및 ELISA에 적합합니다. Protein G로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| ELISA (ELISA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Yeast |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Saccharomyces cerevisiae (strain ATCC 204508/S288c) SNF1 protein (435–633 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.91 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3091714 |
Target Information
Serine/threonine protein kinase essential for release from glucose repression. Catalytic subunit of the AMP-activated protein kinase complex (SNF1 kinase complex, Snf1c), a central regulator of cellular energy homeostasis. In response to decreased intracellular ATP, it activates energy-producing pathways and inhibits energy-consuming processes.
The complex phosphorylates histone H3 (H3S10ph), promoting H3K14ac formation and transcriptional activation via TBP recruitment. It also negatively regulates the HOG1 MAPK pathway during ER stress response and unfolded protein response (UPR).
Under nutrient or energy depletion, it phosphorylates and activates PAS kinase PSK1, leading to TORC1 inhibition. SNF1 also phosphorylates adenylate cyclase CYR1, negatively regulating the protein kinase A pathway, and regulates transcriptional activator CAT8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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