Thermo Fisher Scientific K-Ras Monoclonal Antibody (A8E5)
K-Ras 단백질을 인식하는 Mouse Monoclonal Antibody (Clone A8E5). Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 단백질 A로 정제된 액상 형태로 1 mg/mL 농도. 연구용 전용 제품.
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Thermo Fisher Scientific K-Ras Monoclonal Antibody (A8E5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8E5 |
| Immunogen | Recombinant protein within human KRAS amino acids 2–186 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931387 |
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and contributes to oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in the KRAS gene are associated with leukemia (acute myelogenous and juvenile myelomonocytic), Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome type 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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