Thermo Fisher Scientific UPF1 Monoclonal Antibody (4G3)
UPF1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 ELISA에 적합. 인간 UPF1 단백질에 반응하며, 액상 형태로 제공. NMD 관련 연구 및 RNA 대사 기전 분석에 유용. -20°C 보관, 동결/해동 반복 금지.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific UPF1 Monoclonal Antibody (4G3)
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G3 |
| Immunogen | UPF1 (NP_002902.2, 1019–1116 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GRQKNRFGLP GPSQTNLPNS QASQDVASQP FSQGALTQGY ISMSQPSQMS QPGLSQPELS QDSYLGDEFK SQIDVALSQD STYQGERAYQ HGGVTGLS
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons.
It functions as an ATP-dependent RNA helicase in the cytoplasm and is a component of cytoplasmic P-bodies.
Upf1 phosphorylation mediates translation repression accompanying NMD, facilitating mRNA accessibility to the NMD machinery.
Other active components of NMD, Upf2 and Upf3, show perinuclear and nucleocytoplasmic localization, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: H00005976-M01A_UPF1_Q92900-1_House_mouse.svg, H00005976-M01A_UPF1_Q92900-1_House_mouse_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.