Thermo Fisher Scientific Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4)
Phospho-PKC gamma (Thr514) 특이적 토끼 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 HEK293 세포에서 발현된 재조합 항체입니다. Protein A/G 정제, PBS/glycerol 완충액, -20°C 보관.
- 카탈로그번호
- MA537440
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4)
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PKCgT514-PF4 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr514 of human phospho PKC gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 50% glycerol, 0.10% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897374 |
Additional Formats
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C can be activated by calcium and diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are involved in diverse cellular signaling pathways. PKC also serves as a major receptor for phorbol esters, a class of tumor promoters.
PKC gamma is expressed solely in the brain and spinal cord, localized to neurons. It plays roles in neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies in mice suggest involvement in neuropathic pain development. Mutations in this protein are associated with spinocerebellar ataxia-14 (SCA14).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.