Thermo Fisher Scientific SNAI2 Monoclonal Antibody (OTI4E1), TrueMAB
SNAI2 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 유세포분석에 적합. 인간 시료 반응성. 동결건조 형태로 제공되며 PBS 버퍼에 trehalose 포함. 연구용으로 EMT 관련 단백질 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E1 |
| Immunogen | Full length human recombinant protein of human SNAI2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Slug (SNAI2) is a member of the Snail family of C2H2-type zinc finger transcription factors. It plays a key role in epithelial-mesenchymal transition (EMT) and neural tube formation during vertebrate embryogenesis.
Slug transcription can be induced by FGF, BMP, and TGF-beta, and it represses genes such as E-cadherin and Claudin-1 by binding to E-box promoter regions.
Its overexpression in breast, esophageal, and colorectal carcinomas is correlated with poor prognosis.
Slug also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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