Thermo Fisher Scientific UBC13 Polyclonal Antibody
Rabbit polyclonal antibody for UBC13 detection in human, mouse, and rat samples. Suitable for WB and ELISA applications. Recognizes cytoplasmic and nuclear UBC13 involved in DNA repair and ubiquitination pathways. Supplied as liquid, unconjugated form ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–152 of human Ube2N/Ubc13 (NP_003339.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.91 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804553 |
Product Specific Information
- Immunogen sequence: MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI
- Positive Samples: U-251MG, B cells, Mouse brain, Mouse spleen, Rat brain, Rat testis
- Cellular Location: Cytoplasm, Nucleus
Target Information
The UBE2V1–UBE2N and UBE2V2–UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains, which do not lead to proteasomal degradation. These heterodimers mediate transcriptional activation, regulate cell cycle progression, differentiation, and DNA repair pathways.
They cooperate with E3 ligases such as HLTF, SHPRH, RNF5, RNF135, and TRIM5 to promote Lys-63-linked polyubiquitination of substrates including PCNA, JKAMP, RIG-I/DDX58, and TRAF6, activating NF-κB and MAPK signaling and contributing to antiviral and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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