Thermo Fisher Scientific LGR5 Polyclonal Antibody
LGR5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. WB, IHC, ELISA에 적합하며 고순도 Affinity Chromatography로 정제되었습니다. -20°C 보관, 연구용으로 사용됩니다.
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Thermo Fisher Scientific LGR5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | View publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | View publication |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 824–907 of human LGR5/GPR49 (NP_003658.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.92 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804555 |
Product Specific Information
Immunogen sequence:
NPHFKEDLVS LRKQTYVWTR SKHPSLMSIN SDDVEKQSCD STQALVTFTS SSITYDLPPS SVPSPAYPVT ESCHLSSVAF VPCL
Positive Samples: HT-29, HepG2, SKOV3, A-431, Mouse brain, Rat brain
Cellular Location: Cell membrane, Golgi apparatus, Multi-pass membrane protein, trans-Golgi network membrane
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) are one of the largest families of signaling molecules with more than a thousand members predicted to exist. All GPCRs share a seven-transmembrane structural motif and exist in active and inactive forms. Ligands induce conformational changes leading to signaling via G-proteins and downstream effectors.
Negative regulation mechanisms of GPCRs have significant physiological implications and drive pharmacological research for new drug candidates. Examples of GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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